Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation of Apc. [electronic resource]
Producer: 20170519Description: 723-730 p. digitalISSN:- 1460-2180
- Adenomatous Polyposis Coli Protein -- genetics
- Animals
- Carcinogenesis -- drug effects
- Cytochrome P-450 CYP1A1 -- genetics
- DNA Methylation -- drug effects
- Humans
- Imidazoles -- toxicity
- Intestinal Neoplasms -- chemically induced
- Intestine, Small -- drug effects
- Male
- Mice
- Mice, Transgenic
- Mutation
- Neoplasm Proteins -- biosynthesis
- Obesity -- complications
- Receptors, Leptin -- genetics
- beta Catenin -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
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