IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer. [electronic resource]
Producer: 20170728Description: 3189-99 p. digitalISSN:- 1538-7445
- Adenocarcinoma -- drug therapy
- Animals
- Antibodies, Monoclonal -- pharmacology
- Apoptosis
- Blotting, Western
- Carcinogenesis
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Cell Proliferation
- Disease Models, Animal
- Disease Progression
- Humans
- Immunoenzyme Techniques
- Interleukin-6 -- antagonists & inhibitors
- Lung Neoplasms -- drug therapy
- Mice
- Mutation -- genetics
- NF-kappa B -- genetics
- Neoplasm Staging
- Prognosis
- Proto-Oncogene Proteins p21(ras) -- genetics
- Pulmonary Disease, Chronic Obstructive -- drug therapy
- RNA, Messenger -- genetics
- Real-Time Polymerase Chain Reaction
- Reverse Transcriptase Polymerase Chain Reaction
- STAT3 Transcription Factor -- genetics
- Signal Transduction
- Survival Rate
- Tumor Cells, Cultured
- Tumor Microenvironment -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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