Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers. [electronic resource]
Producer: 20170913Description: 2181-90 p. digitalISSN:- 1558-8238
- Anilides -- administration & dosage
- Animals
- Cell Line, Tumor
- Genes, Neurofibromatosis 1
- Humans
- MAP Kinase Kinase Kinases -- antagonists & inhibitors
- Mechanistic Target of Rapamycin Complex 1
- Mice
- Multiprotein Complexes -- metabolism
- Mutation
- Nerve Sheath Neoplasms -- drug therapy
- Neurofibromin 1 -- genetics
- Nucleocytoplasmic Transport Proteins -- antagonists & inhibitors
- Phosphorylation
- Protein Kinase Inhibitors -- administration & dosage
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Pyridines -- administration & dosage
- Signal Transduction
- TOR Serine-Threonine Kinases -- metabolism
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Publication Type: Journal Article
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