Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes. [electronic resource]
Producer: 20170921Description: 2681-2697 p. digitalISSN:- 1460-2083
- Age of Onset
- Animals
- C9orf72 Protein
- Cell Culture Techniques
- DNA-Binding Proteins -- genetics
- Female
- Frontotemporal Dementia -- genetics
- Frontotemporal Lobar Degeneration -- etiology
- Genes, Regulator -- genetics
- Genome-Wide Association Study
- Genotype
- Humans
- Inclusion Bodies -- metabolism
- Lysosomes -- metabolism
- Male
- Membrane Proteins -- genetics
- Mice
- Nerve Tissue Proteins -- genetics
- Neurons -- metabolism
- Polymorphism, Single Nucleotide -- genetics
- Primary Cell Culture
- Protein Transport -- genetics
- Proteins -- metabolism
- Risk Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
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