The Arg59Trp variant in ANGPTL8 (betatrophin) is associated with total and HDL-cholesterol in American Indians and Mexican Americans and differentially affects cleavage of ANGPTL3. [electronic resource]
Producer: 20180119Description: 128-37 p. digitalISSN:- 1096-7206
- Adult
- Alleles
- Amino Acid Substitution
- Angiopoietin-Like Protein 3
- Angiopoietin-Like Protein 8
- Angiopoietin-like Proteins -- genetics
- Arginine -- genetics
- Blood Glucose -- metabolism
- Cholesterol, HDL -- blood
- Cholesterol, LDL -- blood
- Chromosomes, Human, Pair 19 -- genetics
- Cohort Studies
- Coronary Disease -- blood
- Diabetes Mellitus -- genetics
- Female
- Genome-Wide Association Study
- Hep G2 Cells
- Humans
- Indians, North American -- genetics
- Insulin -- metabolism
- Male
- Mexican Americans -- genetics
- Middle Aged
- Peptide Hormones -- genetics
- Polymorphism, Single Nucleotide
- Tryptophan -- genetics
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Publication Type: Journal Article
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