Autocrine TGF-β/ZEB/microRNA-200 signal transduction drives epithelial-mesenchymal transition: Kinetic models predict minimal drug dose to inhibit metastasis. [electronic resource]
Producer: 20170222Description: 861-70 p. digitalISSN:- 1873-3913
- Animals
- Autocrine Communication -- drug effects
- Benzodioxoles -- pharmacology
- Computer Simulation
- Dogs
- Dose-Response Relationship, Drug
- Epithelial-Mesenchymal Transition -- drug effects
- Gene Regulatory Networks -- drug effects
- Imidazoles -- pharmacology
- Kinetics
- Madin Darby Canine Kidney Cells
- MicroRNAs -- genetics
- Models, Biological
- Neoplasm Metastasis
- Protein Serine-Threonine Kinases -- metabolism
- Pyridines -- pharmacology
- Receptor, Transforming Growth Factor-beta Type I
- Receptors, Transforming Growth Factor beta -- metabolism
- Reproducibility of Results
- Signal Transduction -- drug effects
- Transforming Growth Factor beta -- metabolism
- Zinc Finger E-box-Binding Homeobox 1 -- metabolism
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Publication Type: Journal Article
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