Gankyrin activates mTORC1 signaling by accelerating TSC2 degradation in colorectal cancer. [electronic resource]
Producer: 20170213Description: 83-94 p. digitalISSN:- 1872-7980
- Animals
- Cell Line, Tumor
- Cell Proliferation
- Colorectal Neoplasms -- enzymology
- Enzyme Activation
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Heterografts
- Humans
- Kaplan-Meier Estimate
- Mechanistic Target of Rapamycin Complex 1
- Mice, Inbred BALB C
- Mice, Nude
- Monomeric GTP-Binding Proteins -- metabolism
- Multiprotein Complexes -- metabolism
- Neoplasm Transplantation
- Neuropeptides -- metabolism
- Prognosis
- Proteasome Endopeptidase Complex -- genetics
- Proteolysis
- Proto-Oncogene Proteins -- genetics
- Ras Homolog Enriched in Brain Protein
- Signal Transduction
- TOR Serine-Threonine Kinases -- metabolism
- Time Factors
- Transfection
- Tuberous Sclerosis Complex 2 Protein
- Tumor Burden
- Tumor Suppressor Proteins -- metabolism
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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