Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease. [electronic resource]
Producer: 20170803Description: 1060-1073 p. digitalISSN:- 1468-3288
- Acetylmuramyl-Alanyl-Isoglutamine -- metabolism
- Adolescent
- Adult
- Anti-Bacterial Agents -- pharmacology
- Autophagy -- drug effects
- Bacteria
- Cells, Cultured
- Child
- Child, Preschool
- Chlorpromazine -- pharmacology
- Crohn Disease -- complications
- Dopamine Antagonists -- pharmacology
- Female
- Genetic Diseases, X-Linked -- genetics
- Gentamicins -- pharmacology
- Granuloma -- genetics
- Humans
- Imidazoles -- pharmacology
- Leukocytes, Mononuclear
- Lysosomes
- Macrophages -- drug effects
- Male
- Mutation
- Niemann-Pick Disease, Type C -- complications
- Nod2 Signaling Adaptor Protein -- genetics
- Protein Kinase Inhibitors -- pharmacology
- Pyridazines -- pharmacology
- Receptor-Interacting Protein Serine-Threonine Kinase 2 -- antagonists & inhibitors
- Tumor Necrosis Factor-alpha -- metabolism
- X-Linked Inhibitor of Apoptosis Protein -- deficiency
- Young Adult
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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