Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. [electronic resource]
Producer: 20160823Description: 2612-32 p. digitalISSN:- 1520-4804
- Animals
- Arachidonic Acids -- metabolism
- Blood-Brain Barrier -- metabolism
- Brain -- metabolism
- Cell Membrane -- metabolism
- Drug Design
- Encephalomyelitis, Autoimmune, Experimental -- drug therapy
- Endocannabinoids -- metabolism
- Glycerides -- metabolism
- HEK293 Cells
- Humans
- Mice
- Models, Molecular
- Monoacylglycerol Lipases -- antagonists & inhibitors
- Multiple Sclerosis -- drug therapy
- Mutagenicity Tests
- Neuralgia -- chemically induced
- Organoplatinum Compounds
- Oxaliplatin
- Pain -- drug therapy
- Permeability
- Proteomics
- Receptor, Cannabinoid, CB1 -- agonists
- Receptor, Cannabinoid, CB2 -- agonists
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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