Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening. [electronic resource]
Producer: 20161226Description: 19976 p. digitalISSN:- 2045-2322
- Bortezomib -- pharmacology
- Cell Membrane -- metabolism
- Drug Discovery
- Ether-A-Go-Go Potassium Channels -- chemistry
- Gene Expression
- HEK293 Cells
- High-Throughput Screening Assays
- Humans
- Intracellular Space -- metabolism
- Leupeptins -- pharmacology
- Mutation
- Proteasome Endopeptidase Complex -- metabolism
- Proteasome Inhibitors -- pharmacology
- Protein Interaction Domains and Motifs
- Protein Isoforms
- Protein Transport
- Schizophrenia -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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