BJ-1108, a 6-Amino-2,4,5-Trimethylpyridin-3-ol Analog, Inhibits Serotonin-Induced Angiogenesis and Tumor Growth through PI3K/NOX Pathway. [electronic resource]
Producer: 20160712Description: e0148133 p. digitalISSN:- 1932-6203
- Aminopyridines -- chemical synthesis
- Angiogenesis Inducing Agents -- pharmacology
- Angiogenesis Inhibitors -- chemical synthesis
- Aniline Compounds -- chemical synthesis
- Animals
- Cell Line, Tumor
- Cell Movement -- drug effects
- Chick Embryo
- Chorioallantoic Membrane -- blood supply
- GTP-Binding Protein beta Subunits -- genetics
- Gene Expression Regulation, Neoplastic
- Human Umbilical Vein Endothelial Cells -- cytology
- Humans
- MCF-7 Cells
- NADPH Oxidases -- antagonists & inhibitors
- Neovascularization, Pathologic -- chemically induced
- Oxidation-Reduction
- Phosphatidylinositol 3-Kinases -- genetics
- Phosphoinositide-3 Kinase Inhibitors
- Phosphorylation
- Proto-Oncogene Proteins c-akt -- genetics
- Reactive Oxygen Species -- antagonists & inhibitors
- Receptors, Serotonin, 5-HT1 -- genetics
- Serotonin -- pharmacology
- Signal Transduction
- p38 Mitogen-Activated Protein Kinases -- genetics
- src-Family Kinases -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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