Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies. [electronic resource]
Producer: 20160613Description: E459-68 p. digitalISSN:- 1091-6490
- Animals
- Antigens, CD19 -- immunology
- Antigens, Neoplasm -- immunology
- Azides
- B-Lymphocytes -- immunology
- Basic-Leucine Zipper Transcription Factors -- immunology
- Cell Line, Tumor
- Cytokines -- metabolism
- Cytotoxicity, Immunologic
- Dose-Response Relationship, Immunologic
- Female
- Genes, Reporter
- Genetic Vectors
- Humans
- Immunotherapy, Adoptive -- adverse effects
- Leukemia, B-Cell -- therapy
- Lymphocyte Activation
- Lymphopenia -- etiology
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NOD
- Mice, SCID
- Phenylalanine -- analogs & derivatives
- Protein Engineering -- methods
- Receptors, Antigen, T-Cell -- genetics
- Recombinant Fusion Proteins -- immunology
- Saccharomyces cerevisiae Proteins -- immunology
- Sialic Acid Binding Ig-like Lectin 2 -- immunology
- Single-Chain Antibodies -- genetics
- Structure-Activity Relationship
- T-Cell Antigen Receptor Specificity
- T-Lymphocyte Subsets -- immunology
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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