Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations. [electronic resource]
Producer: 20161110Description: 383-96 p. digitalISSN:- 1097-0134
- Bacillus megaterium -- enzymology
- Bacterial Proteins -- chemistry
- Catalytic Domain
- Crystallography, X-Ray
- Cytochrome P-450 Enzyme System -- chemistry
- Heme -- chemistry
- Hydrogen Bonding
- Mefenamic Acid -- chemistry
- Molecular Docking Simulation
- Molecular Dynamics Simulation
- Mutation, Missense
- Protein Binding
- Protein Structure, Secondary
- Thermodynamics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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