Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds. [electronic resource]
Producer: 20160629Description: 449-460 p. digitalISSN:- 1097-4164
- Aminoquinolines -- pharmacology
- Animals
- Antineoplastic Agents -- pharmacology
- BRCA1 Protein -- deficiency
- BRCA2 Protein -- deficiency
- Biomarkers, Tumor -- deficiency
- Cell Proliferation -- drug effects
- DNA Breaks, Double-Stranded
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm
- G-Quadruplexes -- drug effects
- G2 Phase Cell Cycle Checkpoints -- drug effects
- HEK293 Cells
- Humans
- Intracellular Signaling Peptides and Proteins -- genetics
- Mad2 Proteins -- genetics
- Male
- Mice, Nude
- Molecular Targeted Therapy
- Neoplasms -- drug therapy
- Picolinic Acids -- pharmacology
- Poly(ADP-ribose) Polymerase Inhibitors -- pharmacology
- RNA Interference
- Telomere -- drug effects
- Time Factors
- Transfection
- Tumor Burden -- drug effects
- Tumor Suppressor p53-Binding Protein 1
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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