Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120. [electronic resource]
Producer: 20161213Description: 300-15 p. digitalISSN:- 2159-8290
- Animals
- Antineoplastic Agents -- chemistry
- Cell Line, Tumor
- Cell Transformation, Neoplastic -- genetics
- Disease Models, Animal
- Drug Resistance, Neoplasm
- Ectopic Gene Expression
- Gene Deletion
- Gene Expression
- Humans
- MAP Kinase Signaling System
- Mice
- Models, Molecular
- Phenylurea Compounds -- pharmacology
- Protein Conformation
- Protein Interaction Domains and Motifs -- genetics
- Protein Kinase Inhibitors -- chemistry
- Protein Multimerization
- Proto-Oncogene Proteins B-raf -- antagonists & inhibitors
- Pyrimidines -- pharmacology
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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