ATP-site binding inhibitor effectively targets mTORC1 and mTORC2 complexes in glioblastoma. [electronic resource]
Producer: 20161213Description: 1045-52 p. digitalISSN:- 1791-2423
- Adenosine Triphosphate -- chemistry
- Binding, Competitive
- Brain Neoplasms -- metabolism
- Cell Line, Tumor
- Cell Movement
- Cell Proliferation
- Cell Survival
- Chemotaxis
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Glioblastoma -- metabolism
- Humans
- Indoles -- chemistry
- Insulin -- chemistry
- Mechanistic Target of Rapamycin Complex 1
- Mechanistic Target of Rapamycin Complex 2
- Multiprotein Complexes -- metabolism
- Phenotype
- Phosphorylation -- drug effects
- Protein Binding
- Purines -- chemistry
- S Phase
- Signal Transduction -- drug effects
- Sirolimus -- chemistry
- TOR Serine-Threonine Kinases -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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