Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors. [electronic resource]
Producer: 20160728Description: 1481-92 p. digitalISSN:- 1528-0020
- Adult
- Anemia, Sickle Cell -- blood
- Carrier Proteins -- blood
- Erythroid Precursor Cells -- cytology
- Erythropoiesis -- drug effects
- Fetal Hemoglobin -- biosynthesis
- Gene Expression Regulation, Developmental
- Genetic Vectors -- genetics
- Hematopoietic Stem Cells -- drug effects
- Histone Demethylases -- blood
- Humans
- Ikaros Transcription Factor -- blood
- Kruppel-Like Transcription Factors -- blood
- Lentivirus -- genetics
- Multiple Myeloma -- blood
- Neoplasm Proteins -- biosynthesis
- Nuclear Proteins -- blood
- Proteasome Endopeptidase Complex -- metabolism
- RNA Interference
- RNA, Small Interfering -- genetics
- Repressor Proteins
- SOXD Transcription Factors -- blood
- Thalidomide -- analogs & derivatives
- Transcription, Genetic -- drug effects
- beta-Globins -- biosynthesis
- gamma-Globins -- biosynthesis
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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