Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. [electronic resource]
Producer: 20160524Description: 78-83 p. digitalISSN:- 1546-170X
- Aniline Compounds -- pharmacology
- Animals
- Antineoplastic Agents -- pharmacology
- Antiviral Agents -- pharmacology
- Apoptosis -- drug effects
- B-Lymphocytes -- drug effects
- Blotting, Western
- Cell Cycle
- Cell Line
- Cell Survival -- drug effects
- Cellular Senescence
- Colony-Forming Units Assay
- Cyclin-Dependent Kinase Inhibitor p16 -- drug effects
- DNA Damage
- Ganciclovir -- pharmacology
- Gene Knockdown Techniques
- Hematopoietic Stem Cells -- drug effects
- Humans
- Mice
- Microscopy
- Muscle, Skeletal -- cytology
- Myoblasts -- drug effects
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- RNA, Messenger -- drug effects
- Rejuvenation
- Sulfonamides -- pharmacology
- Whole-Body Irradiation
- bcl-X Protein -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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