Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Legius Syndrome and Neurofibromatosis Type 1. [electronic resource]
Producer: 20160706Description: 3124-34 p. digitalISSN:- 1083-351X
- Adaptor Proteins, Signal Transducing
- Amino Acid Transport System A
- Cafe-au-Lait Spots -- genetics
- Epidermal Growth Factor -- metabolism
- Female
- Genes, Reporter
- Genetic Association Studies
- HEK293 Cells
- Humans
- Intracellular Signaling Peptides and Proteins -- chemistry
- Kinetics
- MAP Kinase Signaling System
- Male
- Membrane Proteins -- chemistry
- Models, Molecular
- Mutation, Missense
- Neurofibromatosis 1 -- genetics
- Neurofibromin 1 -- chemistry
- Peptide Fragments -- chemistry
- Point Mutation
- Protein Conformation
- Protein Interaction Domains and Motifs
- Proto-Oncogene Proteins p21(ras) -- agonists
- Recombinant Fusion Proteins -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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