Stimulation of adenosine A2A receptors reduces intracellular cholesterol accumulation and rescues mitochondrial abnormalities in human neural cell models of Niemann-Pick C1. [electronic resource]
Producer: 20161213Description: 155-62 p. digitalISSN:- 1873-7064
- Adenosine -- analogs & derivatives
- Adenosine A2 Receptor Agonists -- pharmacology
- Calcium -- metabolism
- Carrier Proteins -- genetics
- Cell Line, Tumor
- Cell Membrane -- metabolism
- Cholesterol -- metabolism
- Cyclic AMP-Dependent Protein Kinases -- metabolism
- Humans
- Intracellular Signaling Peptides and Proteins
- Membrane Glycoproteins -- genetics
- Mitochondria -- metabolism
- Neurons -- metabolism
- Niemann-Pick C1 Protein
- Niemann-Pick Disease, Type C -- metabolism
- Oligodendroglia -- metabolism
- Phenethylamines -- pharmacology
- Receptor, Adenosine A2A -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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