Normal human CD4(+) helper T cells express Kv1.1 voltage-gated K(+) channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB non-canonical pathway. [electronic resource]
Producer: 20161213Description: 137-57 p. digitalISSN:- 1435-1463
- Animals
- Autoimmune Diseases -- immunology
- Blotting, Western
- CD4-Positive T-Lymphocytes -- immunology
- Electrophoretic Mobility Shift Assay
- Female
- Humans
- Immunohistochemistry
- Inflammation -- immunology
- Kv1.1 Potassium Channel -- metabolism
- Male
- Mice
- Mice, SCID
- NF-kappa B -- immunology
- Patch-Clamp Techniques
- Polymerase Chain Reaction
- Signal Transduction -- immunology
- Tumor Necrosis Factor-alpha -- metabolism
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Publication Type: Journal Article
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