Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. [electronic resource]
Producer: 20160401Description: 1556-68 p. digitalISSN:- 1476-4679
- Animals
- Astrocytes -- cytology
- Blotting, Western
- Brain Neoplasms -- genetics
- Cell Line, Tumor
- Cell Proliferation
- Cells, Cultured
- Citric Acid Cycle
- Coculture Techniques
- Female
- Glioblastoma -- genetics
- Glutamate-Ammonia Ligase -- genetics
- Glutamic Acid -- metabolism
- Glutamine -- metabolism
- Humans
- Male
- Mice, Inbred NOD
- Mice, SCID
- Models, Biological
- Neoplastic Stem Cells -- metabolism
- Nucleotides -- biosynthesis
- Rats, Sprague-Dawley
- Reverse Transcriptase Polymerase Chain Reaction
- Transplantation, Heterologous
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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