Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB. [electronic resource]
Producer: 20161213Description: 1323-40 p. digitalISSN:- 1949-2553
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- Bortezomib -- pharmacology
- Casein Kinase II -- antagonists & inhibitors
- Cell Line, Tumor
- Cell Survival -- drug effects
- Drug Synergism
- Endoplasmic Reticulum Chaperone BiP
- Endoplasmic Reticulum Stress -- drug effects
- Heat-Shock Proteins -- metabolism
- Humans
- Jurkat Cells
- Microscopy, Fluorescence
- Naphthyridines -- pharmacology
- Neoplastic Stem Cells -- drug effects
- Phenazines
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma -- blood
- Precursor Cell Lymphoblastic Leukemia-Lymphoma -- blood
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma -- blood
- Transcription Factor RelA -- metabolism
- Unfolded Protein Response -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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