Small Molecule T315 Promotes Casitas B-Lineage Lymphoma-Dependent Degradation of Epidermal Growth Factor Receptor via Y1045 Autophosphorylation. [electronic resource]
Producer: 20160812Description: 753-66 p. digitalISSN:- 1535-4970
- Adaptor Proteins, Signal Transducing -- drug effects
- Adenocarcinoma -- drug therapy
- Adenocarcinoma of Lung
- Afatinib
- Animals
- Antineoplastic Agents -- adverse effects
- Blotting, Western
- Cell Proliferation -- drug effects
- Drug Combinations
- Drug Resistance, Neoplasm -- drug effects
- Enzyme Assays
- ErbB Receptors -- antagonists & inhibitors
- Humans
- Lung Neoplasms -- drug therapy
- Mass Spectrometry
- Mice
- Mutation -- genetics
- Protein Kinase Inhibitors -- adverse effects
- Proto-Oncogene Proteins c-cbl -- drug effects
- Quinazolines -- adverse effects
- Real-Time Polymerase Chain Reaction
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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