Enhancing SHP-1 expression with 5-azacytidine may inhibit STAT3 activation and confer sensitivity in lestaurtinib (CEP-701)-resistant FLT3-ITD positive acute myeloid leukemia. [electronic resource]
Producer: 20160819Description: 869 p. digitalISSN:- 1471-2407
- Apoptosis -- drug effects
- Azacitidine -- pharmacology
- Carbazoles -- pharmacology
- Cell Line, Tumor
- Cells, Cultured
- DNA Methylation
- Drug Resistance, Neoplasm -- genetics
- Furans
- Gene Duplication
- Gene Expression Regulation, Leukemic -- drug effects
- Humans
- Leukemia, Myeloid, Acute -- drug therapy
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 -- genetics
- STAT3 Transcription Factor -- metabolism
- fms-Like Tyrosine Kinase 3 -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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