IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide. [electronic resource]
Producer: 20160920Description: 39877-90 p. digitalISSN:- 1949-2553
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- Cell Line, Tumor
- Cell Survival -- drug effects
- DNA Breaks, Double-Stranded -- drug effects
- Dacarbazine -- administration & dosage
- Drug Administration Schedule
- Drug Resistance, Neoplasm -- drug effects
- Drug Synergism
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Humans
- Imidazoles -- administration & dosage
- Melanoma -- drug therapy
- Mice, Inbred BALB C
- Mice, Nude
- Mutation
- Proto-Oncogene Proteins B-raf -- genetics
- Pyrazines -- administration & dosage
- Receptor, IGF Type 1 -- antagonists & inhibitors
- Survival Analysis
- Temozolomide
- Tumor Suppressor Protein p53 -- genetics
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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