NecroX-5 suppresses IgE/Ag-stimulated anaphylaxis and mast cell activation by regulating the SHP-1-Syk signaling module. [electronic resource]
Producer: 20161020Description: 198-209 p. digitalISSN:- 1398-9995
- Anaphylaxis -- drug therapy
- Animals
- Antigens -- immunology
- Arachidonate 5-Lipoxygenase -- metabolism
- Calcium -- metabolism
- Cell Degranulation -- drug effects
- Cell Line
- Cyclooxygenase 2 -- metabolism
- Cytokines -- biosynthesis
- Disease Models, Animal
- Heterocyclic Compounds, 4 or More Rings -- pharmacology
- Immunoglobulin E -- immunology
- Intracellular Signaling Peptides and Proteins -- metabolism
- Leukotriene C4 -- biosynthesis
- Male
- Mast Cells -- drug effects
- Mice
- Prostaglandin D2 -- metabolism
- Protein Binding
- Protein Tyrosine Phosphatase, Non-Receptor Type 6 -- metabolism
- Protein-Tyrosine Kinases -- metabolism
- Signal Transduction -- drug effects
- Sulfones -- pharmacology
- Syk Kinase
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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