Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates. [electronic resource]
Producer: 20160202Description: 8110-27 p. digitalISSN:- 1520-4804
- Antiviral Agents -- chemical synthesis
- DNA Polymerase I -- antagonists & inhibitors
- DNA Polymerase beta -- antagonists & inhibitors
- DNA Primers
- Drug Design
- HIV Reverse Transcriptase -- antagonists & inhibitors
- HIV-1 -- drug effects
- Herpesvirus 3, Human -- drug effects
- Humans
- Molecular Conformation
- Nucleic Acid Synthesis Inhibitors -- chemical synthesis
- Organophosphonates -- chemical synthesis
- Plasmids -- genetics
- Reverse Transcriptase Inhibitors -- chemical synthesis
- Simplexvirus -- drug effects
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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