PI3K-mTORC2 but not PI3K-mTORC1 regulates transcription of HIF2A/EPAS1 and vascularization in neuroblastoma. [electronic resource]
Producer: 20160225Description: 4617-28 p. digitalISSN:- 1538-7445
- Adaptor Proteins, Signal Transducing -- genetics
- Animals
- Antigens, CD -- genetics
- Basic Helix-Loop-Helix Transcription Factors -- biosynthesis
- Cell Line, Tumor
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- biosynthesis
- Mechanistic Target of Rapamycin Complex 1
- Mechanistic Target of Rapamycin Complex 2
- Mice
- Mice, Nude
- Multiprotein Complexes -- metabolism
- Neovascularization, Pathologic -- genetics
- Neuroblastoma -- blood supply
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Proto-Oncogene Proteins c-akt -- genetics
- RNA Interference
- RNA, Messenger -- biosynthesis
- RNA, Small Interfering
- Receptor, IGF Type 1
- Receptor, IGF Type 2 -- genetics
- Receptor, Insulin -- genetics
- Receptors, Somatomedin -- genetics
- Regulatory-Associated Protein of mTOR
- Signal Transduction -- physiology
- TOR Serine-Threonine Kinases -- metabolism
- Transcription, Genetic -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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