Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells. [electronic resource]
Producer: 20160308Description: 231-9 p. digitalISSN:- 1096-0333
- Antioxidants -- metabolism
- Arsenites -- toxicity
- Bronchi -- drug effects
- Carcinogens -- toxicity
- Cell Line
- Cell Movement -- drug effects
- Cell Proliferation -- drug effects
- Cell Transformation, Neoplastic -- chemically induced
- Enzyme Activation
- Epithelial Cells -- drug effects
- Heme Oxygenase-1 -- metabolism
- Humans
- Intracellular Signaling Peptides and Proteins -- metabolism
- Kelch-Like ECH-Associated Protein 1
- Lung Neoplasms -- chemically induced
- Malondialdehyde -- metabolism
- NAD(P)H Dehydrogenase (Quinone) -- metabolism
- NF-E2-Related Factor 2 -- agonists
- Neoplasm Invasiveness
- Oxidative Stress -- drug effects
- Phenotype
- RNA Interference
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- drug effects
- Sodium Compounds -- toxicity
- Superoxide Dismutase -- metabolism
- Time Factors
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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