2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells. [electronic resource]
Producer: 20170309Description: 2187-2200 p. digitalISSN:- 1432-0738
- Antioxidants -- pharmacology
- Apoptosis -- drug effects
- Arsenites -- toxicity
- Cell Line
- Cytoprotection
- Dose-Response Relationship, Drug
- Down-Regulation
- Enzyme Inhibitors -- pharmacology
- Heme Oxygenase-1 -- antagonists & inhibitors
- Humans
- Kidney Tubules, Proximal -- drug effects
- Mitochondria -- drug effects
- Mitogen-Activated Protein Kinases -- metabolism
- NF-E2-Related Factor 2 -- metabolism
- NF-kappa B -- metabolism
- Nuclear Proteins -- metabolism
- Oxidative Stress -- drug effects
- Pyrazines -- pharmacology
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- drug effects
- Sodium Compounds -- toxicity
- Time Factors
- Transcription Factor AP-1 -- metabolism
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Publication Type: Journal Article
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