Transformation of alkylating regimen of thiotepa into tepa determines the disease progression through GSTP1 gene polymorphism for metastatic breast cancer patients receiving thiotepa containing salvage chemotherapy. [electronic resource]
Producer: 20151224Description: 914-22 p. digitalISSN:- 0946-1965
- Aged
- Antineoplastic Agents, Alkylating -- adverse effects
- Biotransformation
- Breast Neoplasms -- drug therapy
- Chi-Square Distribution
- China
- Cytochrome P-450 CYP2B6 -- genetics
- Cytochrome P-450 CYP3A -- genetics
- Disease Progression
- Disease-Free Survival
- Female
- Genotype
- Glutathione S-Transferase pi -- genetics
- Humans
- Logistic Models
- Middle Aged
- Multivariate Analysis
- Neoplasm Metastasis
- Odds Ratio
- Patient Selection
- Pharmacogenetics
- Phenotype
- Polymorphism, Single Nucleotide
- Retrospective Studies
- Risk Factors
- Salvage Therapy
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- Thiotepa -- adverse effects
- Time Factors
- Treatment Outcome
- Triethylenephosphoramide -- adverse effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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