Mevastatin ameliorates sphingosine 1-phosphate-induced COX-2/PGE2-dependent cell migration via FoxO1 and CREB phosphorylation and translocation. [electronic resource]
Producer: 20161025Description: 5360-76 p. digitalISSN:- 1476-5381
- Animals
- Anti-Inflammatory Agents -- pharmacology
- Bronchoalveolar Lavage Fluid -- cytology
- Cell Movement -- drug effects
- Cyclic AMP Response Element-Binding Protein -- metabolism
- Cyclooxygenase 2 -- genetics
- Dinoprostone -- metabolism
- Elafin -- metabolism
- Forkhead Box Protein O1
- Forkhead Transcription Factors -- metabolism
- Humans
- Hydrogen Peroxide -- metabolism
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Leukocyte Count
- Lovastatin -- analogs & derivatives
- Lysophospholipids -- pharmacology
- Male
- Membrane Glycoproteins -- metabolism
- Mice, Inbred ICR
- Myocytes, Smooth Muscle -- drug effects
- NADPH Oxidase 2
- NADPH Oxidases -- metabolism
- PPAR gamma -- metabolism
- Phosphorylation -- drug effects
- Proto-Oncogene Proteins c-akt -- genetics
- RNA, Small Interfering -- genetics
- Sphingosine -- analogs & derivatives
- TOR Serine-Threonine Kinases -- genetics
- Trachea -- cytology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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