Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC. [electronic resource]
Producer: 20160209Description: 4398-406 p. digitalISSN:- 1538-7445
- Animals
- Antineoplastic Agents -- pharmacology
- Benzamides -- pharmacology
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Cell Line, Tumor
- Disease Models, Animal
- Drug Resistance, Neoplasm
- Drug Synergism
- Gene Library
- Genes, Essential
- Genomics -- methods
- Humans
- Lung Neoplasms -- drug therapy
- Morpholines -- pharmacology
- Piperazines -- pharmacology
- Protein Binding
- Protein Kinase Inhibitors -- pharmacology
- Pyrazoles -- pharmacology
- Pyrimidines
- RNA Interference
- RNA, Small Interfering -- genetics
- Receptor, Fibroblast Growth Factor, Type 1 -- antagonists & inhibitors
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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