Chronic Exposure of Female Mice to an Environmental Level of Perfluorooctane Sulfonate Suppresses Estrogen Synthesis Through Reduced Histone H3K14 Acetylation of the StAR Promoter Leading to Deficits in Follicular Development and Ovulation. [electronic resource]
Producer: 20160908Description: 368-79 p. digitalISSN:- 1096-0929
- Acetylation
- Alkanesulfonic Acids -- toxicity
- Animals
- Down-Regulation
- Endocrine Disruptors -- toxicity
- Environmental Exposure -- adverse effects
- Estradiol -- biosynthesis
- Estrous Cycle -- drug effects
- Female
- Fluorocarbons -- toxicity
- Histones -- metabolism
- Hypothalamo-Hypophyseal System -- drug effects
- Mice, Inbred ICR
- Neurons -- drug effects
- Neuropeptides -- genetics
- Ovarian Follicle -- drug effects
- Ovary -- drug effects
- Ovulation -- drug effects
- Phosphoproteins -- genetics
- Progesterone -- blood
- Promoter Regions, Genetic
- RNA, Messenger -- metabolism
- Risk Assessment
- Signal Transduction -- drug effects
- Time Factors
- Toxicity Tests, Chronic
- Steroidogenic Acute Regulatory Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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