Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances. [electronic resource]
Producer: 20161014Description: 636-43 p. digitalISSN:- 1099-081X
- Animals
- Biotransformation
- Chromatography, High Pressure Liquid
- Chromatography, Reverse-Phase
- Cytochrome P-450 CYP2C19 -- genetics
- Cytochrome P-450 CYP2C9 -- genetics
- Histamine H1 Antagonists, Non-Sedating -- chemistry
- Humans
- Isoenzymes -- genetics
- Loratadine -- analogs & derivatives
- Macaca fascicularis -- metabolism
- Molecular Structure
- Oxidation-Reduction
- Recombinant Proteins -- metabolism
- Spectrometry, Mass, Electrospray Ionization
- Substrate Specificity
- Tandem Mass Spectrometry
- Xenobiotics -- chemistry
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Publication Type: Journal Article
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