Prognostic Value of BRAF, PI3K, PTEN, EGFR Copy Number, Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy. [electronic resource]
Producer: 20160905Description: 397-408 p. digitalISSN:- 1179-2000
- Adult
- Aged
- Aged, 80 and over
- Amphiregulin
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Class I Phosphatidylinositol 3-Kinases
- Codon
- Colorectal Neoplasms -- drug therapy
- DNA Copy Number Variations
- DNA Mutational Analysis
- Disease-Free Survival
- EGF Family of Proteins -- genetics
- Epiregulin -- genetics
- ErbB Receptors -- antagonists & inhibitors
- Female
- Gene Dosage
- Gene Expression
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Multivariate Analysis
- Mutation, Missense
- Neoplasm Metastasis
- PTEN Phosphohydrolase -- genetics
- Phosphatidylinositol 3-Kinases -- genetics
- Prognosis
- Proportional Hazards Models
- Proto-Oncogene Proteins B-raf -- genetics
- Proto-Oncogene Proteins p21(ras) -- genetics
- ROC Curve
- Retrospective Studies
- Treatment Outcome
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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