Restriction of spontaneous and prednisolone-induced leptin production to dedifferentiated state in human hip OA chondrocytes: role of Smad1 and β-catenin activation. [electronic resource]
Producer: 20161017Description: 315-24 p. digitalISSN:- 1522-9653
- Activin Receptors, Type II -- drug effects
- Adult
- Aged
- Aged, 80 and over
- Cartilage, Articular -- cytology
- Cell Dedifferentiation -- drug effects
- Chondrocytes -- drug effects
- Collagen Type X -- drug effects
- Core Binding Factor Alpha 1 Subunit -- drug effects
- Female
- Glucocorticoids -- pharmacology
- Glycogen Synthase Kinase 3 -- drug effects
- Humans
- In Vitro Techniques
- Leptin -- metabolism
- Lymphotoxin-alpha -- drug effects
- Male
- Matrix Metalloproteinase 13 -- drug effects
- Middle Aged
- Osteoarthritis, Hip -- genetics
- Prednisolone -- pharmacology
- Protein Serine-Threonine Kinases -- drug effects
- RNA, Messenger -- drug effects
- Receptor, Transforming Growth Factor-beta Type I
- Receptors, Transforming Growth Factor beta -- drug effects
- SOX9 Transcription Factor -- drug effects
- Smad1 Protein -- drug effects
- Smad2 Protein -- drug effects
- Smad5 Protein -- drug effects
- Wnt Signaling Pathway -- drug effects
- beta Catenin -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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