HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia. [electronic resource]
Producer: 20160601Description: 219-28 p. digitalISSN:- 1476-5551
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- analysis
- Bcl-2-Like Protein 11
- Cell Line, Tumor
- HSP90 Heat-Shock Proteins -- antagonists & inhibitors
- Humans
- Isoxazoles -- therapeutic use
- Membrane Proteins -- analysis
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
- Proto-Oncogene Proteins -- analysis
- Proto-Oncogene Proteins c-bcl-2 -- analysis
- Resorcinols -- therapeutic use
- TYK2 Kinase -- metabolism
- bcl-Associated Death Protein -- analysis
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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