Modelling of drug-induced QT-interval prolongation: estimation approaches and translational opportunities. [electronic resource]
Producer: 20160810Description: 659-79 p. digitalISSN:- 1573-8744
- Action Potentials
- Animals
- Anti-Bacterial Agents -- blood
- Bayes Theorem
- Dogs
- ERG1 Potassium Channel
- Ether-A-Go-Go Potassium Channels -- antagonists & inhibitors
- Female
- Fluoroquinolones -- blood
- HEK293 Cells
- Heart Conduction System -- drug effects
- Heart Rate -- drug effects
- Humans
- Models, Animal
- Models, Cardiovascular
- Models, Statistical
- Moxifloxacin
- Patch-Clamp Techniques
- Potassium Channel Blockers -- toxicity
- Randomized Controlled Trials as Topic
- Risk Assessment
- Species Specificity
- Torsades de Pointes -- chemically induced
- Toxicity Tests
- Transfection
- Translational Research, Biomedical
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Publication Type: Comparative Study; Journal Article
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