The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. [electronic resource]
Producer: 20161104Description: 274-82 p. digitalISSN:- 1559-0100
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Benzamides -- pharmacology
- Caspase 3 -- metabolism
- Cell Line, Tumor
- Cell Survival -- drug effects
- Drug Synergism
- Glycine
- HSP90 Heat-Shock Proteins -- antagonists & inhibitors
- Histone Deacetylase Inhibitors -- pharmacology
- Humans
- Hydroxamic Acids -- pharmacology
- Indazoles -- pharmacology
- Phosphorylation -- drug effects
- Proto-Oncogene Proteins c-akt -- metabolism
- Thyroid Carcinoma, Anaplastic -- drug therapy
- Thyroid Neoplasms -- drug therapy
- Vorinostat
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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