Determination of the impurities in drug products containing montelukast and in silico/in vitro genotoxicological assessments of sulfoxide impurity. [electronic resource]
Producer: 20151116Description: 90-9 p. digitalISSN:- 1879-3169
- Acetates -- analysis
- Adult
- Animals
- Anti-Asthmatic Agents -- analysis
- Cells, Cultured
- Chemistry, Pharmaceutical
- Chromatography, High Pressure Liquid
- Chromatography, Reverse-Phase
- Chromosome Aberrations -- chemically induced
- Computer Simulation
- Cyclopropanes
- Dose-Response Relationship, Drug
- Drug Contamination
- Female
- Gene Expression Regulation, Bacterial -- drug effects
- Humans
- Leukotriene Antagonists -- analysis
- Lymphocytes -- drug effects
- Male
- Mitosis -- drug effects
- Mitotic Index
- Mutagenicity Tests
- Mutation
- Quinolines -- analysis
- Rats, Sprague-Dawley
- Risk Assessment
- Sulfides
- Sulfoxides -- analysis
- Turkey
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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