Transforming growth factor-β1 induces type II collagen and aggrecan expression via activation of extracellular signal-regulated kinase 1/2 and Smad2/3 signaling pathways. [electronic resource]
Producer: 20160624Description: 5573-9 p. digitalISSN:- 1791-3004
- Aggrecans -- agonists
- Animals
- Cartilage, Articular -- cytology
- Chondrocytes -- cytology
- Collagen Type II -- agonists
- Enzyme Activation
- Female
- Flavonoids -- pharmacology
- Gene Expression Regulation
- Humans
- Imidazoles -- pharmacology
- Isoquinolines -- pharmacology
- Mitogen-Activated Protein Kinase 1 -- genetics
- Mitogen-Activated Protein Kinase 3 -- genetics
- Phosphorylation -- drug effects
- Primary Cell Culture
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Pyridines -- pharmacology
- Pyrroles -- pharmacology
- Quinoxalines -- pharmacology
- Rats
- Rats, Sprague-Dawley
- Receptor, Transforming Growth Factor-beta Type I
- Receptors, Transforming Growth Factor beta -- antagonists & inhibitors
- Recombinant Proteins -- metabolism
- Signal Transduction
- Smad2 Protein -- agonists
- Smad3 Protein -- agonists
- Transforming Growth Factor beta1 -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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