Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor. [electronic resource]
Producer: 20151105Description: 19888-99 p. digitalISSN:- 1083-351X
- ATP Binding Cassette Transporter, Subfamily B, Member 11
- ATP-Binding Cassette Transporters -- antagonists & inhibitors
- Animals
- Benzamides -- chemistry
- Crystallography, X-Ray
- Gene Expression Regulation
- Glucose-6-Phosphatase -- antagonists & inhibitors
- Hep G2 Cells
- Hepatocytes -- cytology
- Humans
- Isoxazoles -- antagonists & inhibitors
- Male
- Mice
- Mice, Knockout
- Molecular Docking Simulation
- Mutation
- Phosphoenolpyruvate Carboxykinase (ATP) -- antagonists & inhibitors
- Primary Cell Culture
- Protein Isoforms -- agonists
- Receptors, Cytoplasmic and Nuclear -- agonists
- Receptors, Leptin -- deficiency
- Recombinant Proteins -- genetics
- Retinoid X Receptors -- agonists
- Signal Transduction
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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