Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors. [electronic resource]
Producer: 20160520Description: 3711-5 p. digitalISSN:- 1464-3405
- Animals
- Antiviral Agents -- administration & dosage
- Carbamates
- Cell Line -- drug effects
- Chemistry Techniques, Synthetic
- Chlorocebus aethiops
- Drug Design
- Drug Evaluation, Preclinical -- methods
- Hepacivirus -- drug effects
- Humans
- Imidazoles -- pharmacology
- Molecular Targeted Therapy
- Mutation
- Pyrrolidines
- Structure-Activity Relationship
- Valine -- analogs & derivatives
- Vero Cells -- drug effects
- Viral Nonstructural Proteins -- antagonists & inhibitors
- Virus Replication -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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