A novel Monoclonal Antibody against Notch1 Targets Leukemia-associated Mutant Notch1 and Depletes Therapy Resistant Cancer Stem Cells in Solid Tumors. [electronic resource]
Producer: 20160331Description: 11012 p. digitalISSN:- 2045-2322
- Animals
- Antibodies, Monoclonal -- pharmacology
- Antibody Affinity
- Antineoplastic Agents -- pharmacology
- Doxorubicin -- pharmacology
- Drug Resistance, Neoplasm
- Drug Synergism
- Female
- HEK293 Cells
- Humans
- Mice, Nude
- Mutation
- Neoplastic Stem Cells -- drug effects
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
- Receptor, Notch1 -- antagonists & inhibitors
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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