Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden. [electronic resource]
Producer: 20160204Description: 114 p. digitalISSN:- 1476-4598
- Apoptosis -- drug effects
- Autophagy -- drug effects
- Caspase 3 -- metabolism
- Cell Line, Tumor
- Energy Metabolism -- drug effects
- Homeostasis -- drug effects
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell -- pathology
- Membrane Potential, Mitochondrial -- drug effects
- Mitochondria -- drug effects
- Necrosis
- Nucleosides -- chemistry
- Oncogenes
- Organometallic Compounds -- chemistry
- Proto-Oncogene Proteins -- genetics
- Reactive Oxygen Species -- metabolism
- Risk Factors
- Stromal Cells -- drug effects
- Tumor Suppressor Protein p53 -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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