Codon-optimized filovirus DNA vaccines delivered by intramuscular electroporation protect cynomolgus macaques from lethal Ebola and Marburg virus challenges. [electronic resource]
Producer: 20160504Description: 1991-2004 p. digitalISSN:- 2164-554X
- Animals
- Antibodies, Neutralizing -- blood
- Antibodies, Viral -- blood
- Codon
- Disease Models, Animal
- Drug Evaluation, Preclinical
- Electroporation
- Enzyme-Linked Immunosorbent Assay
- Enzyme-Linked Immunospot Assay
- Female
- Filoviridae -- genetics
- Glycoproteins -- genetics
- Hemorrhagic Fever, Ebola -- prevention & control
- Immunoglobulin G -- blood
- Injections, Intramuscular
- Interferon-gamma -- metabolism
- Leukocytes, Mononuclear -- immunology
- Macaca fascicularis
- Male
- Marburg Virus Disease -- prevention & control
- Neutralization Tests
- Plasmids
- Survival Analysis
- Treatment Outcome
- Vaccines, DNA -- administration & dosage
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Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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