Discovery of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases. [electronic resource]
Producer: 20160223Description: 2484-7 p. digitalISSN:- 1464-3405
- Adenosine -- chemical synthesis
- Antiviral Agents -- chemical synthesis
- Aza Compounds -- chemistry
- DNA-Directed DNA Polymerase -- chemistry
- Drug Evaluation, Preclinical
- Nucleic Acid Synthesis Inhibitors -- chemical synthesis
- RNA -- chemistry
- RNA, Mitochondrial
- RNA-Dependent RNA Polymerase -- antagonists & inhibitors
- Respiratory Syncytial Viruses -- drug effects
- Structure-Activity Relationship
- Virus Replication -- drug effects
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Publication Type: Journal Article
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