Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage. [electronic resource]
Producer: 20160321Description: 930-49 p. digitalISSN:- 1757-4684
- Animals
- Apoptosis
- Cell Cycle Checkpoints -- drug effects
- Cell Proliferation -- drug effects
- DNA Damage
- Disease Models, Animal
- Gene Deletion
- Lung Neoplasms -- drug therapy
- Mice
- Mutant Proteins -- genetics
- Mutation, Missense
- Oncogene Protein p21(ras) -- genetics
- Survival Analysis
- Telomere -- metabolism
- Telomeric Repeat Binding Protein 1 -- antagonists & inhibitors
- Treatment Outcome
- Tumor Suppressor Protein p53 -- deficiency
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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